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Resource "KDN5" Version "1" (PlanDefinition)

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National Comprehensive Cancer Network

Chemotherapy Order Template

Kidney Cancer

Gemcitabine/CARBOplatin

KDN5

INDICATION:

Metastatic or Relapsed – Collecting Duct/Medullary Subtypes

REFERENCES:

  1. NCCN Guidelines® for Kidney Cancer. V.3.2015.
  2. Oudard S, et al. J Urol. 2007;177(5):1698-702. a

NCCN SUPPORTIVE CARE:

  1. Emetic Risk:
    Day 1 Moderate
    Day 8 Low
  2. Fever Neutropenia Risk:
    Refer to NCCN Guidelines for Myeloid Growth Factors. V.2.2014

CHEMOTHERAPY REGIMEN

21-day cycle for 6 cycles

  • Gemcitabine 1250 mg/m2 IV over 30 minutes on Days 1 and 8
  • CARBOplatin AUC 5 IV over 30 minutes on Day 1

{
  "resourceType" : "PlanDefinition",
  "id" : "KDN5",
  "meta" : {
    "versionId" : "1",
    "lastUpdated" : "2018-12-14T02:02:46.973Z"
  },
  "text" : {
    "status" : "additional",
    "div" : "<div xmlns=\"http://www.w3.org/1999/xhtml\">\n <table style=\"width: 100%;\">\n <tr>\n <td>\n <!-- link to NCCN image -->\n <div style=\"width: 200px; height: 100px; vertical-align: top;\">National Comprehensive Cancer Network</div>\n </td>\n <td>\n <h3>Chemotherapy Order Template</h3>\n <h1>Kidney Cancer</h1>\n <h2>Gemcitabine/CARBOplatin</h2>\n </td>\n <td style=\"text-align: right; vertical-align: top;\">KDN5</td>\n </tr>\n </table>\n <table style=\"width: 100%; border-top: 1px solid; border-bottom: 1px solid;\">\n <tr>\n <td style=\"width: 33%; border-right: 1px solid; vertical-align: top\">\n <h4>INDICATION:</h4>\n <p>Metastatic or Relapsed &#8211; Collecting Duct/Medullary Subtypes</p>\n </td>\n <td style=\"width: 34%; border-right: 1px solid; vertical-align: top\">\n <h4>REFERENCES:</h4>\n <ol>\n <li><a href=\"http://www.example.org/professionals/physician_gls/PDF/kidney.pdf\">NCCN Guidelines&#174; for Kidney Cancer. V.3.2015.</a></li>\n <li><a href=\"http://www.ncbi.nlm.nih.gov/pubmed?term=%22The+Journal+of+urology%22%5BJour%5D+AND+1698%5Bpage%5D+AND+2007%5Bpdat%5D+AND+Oudard+S%5Bauthor%5D\">Oudard S, et al. <em>J Urol</em>. 2007;177(5):1698-702.</a><sup>\n <a href=\"http://www.example.org/OrderTemplates/PDF/appendix_E.pdf\">a</a></sup>\n </li>\n </ol>\n </td>\n <td style=\"width: 33%; vertical-align: top\">\n <h4>NCCN SUPPORTIVE CARE:</h4>\n <ol>\n <li>\n <i>Emetic Risk:</i>\n <table>\n <tr>\n <td>Day 1</td>\n <td>Moderate</td>\n </tr>\n <tr>\n <td>Day 8</td>\n <td>Low</td>\n </tr>\n </table>\n </li>\n <li>\n <i>Fever Neutropenia Risk:</i><br/>\n Refer to <a href=\"http://www.example.org/professionals/physician_gls/PDF/myeloid_growth.pdf\">NCCN Guidelines for Myeloid Growth Factors. V.2.2014</a>\n </li>\n </ol>\n </td>\n </tr>\n </table>\n <!-- same as the regimen section of the Composition resource only this version is without the style guide notes -->\n <h4>CHEMOTHERAPY REGIMEN</h4>\n <p>\n <i>21-day cycle for 6 cycles</i>\n </p>\n <ul>\n <li>Gemcitabine 1250 mg/m<sup>2</sup> IV over 30 minutes on Days 1 and 8</li>\n <li>CARBOplatin AUC 5 IV over 30 minutes on Day 1</li>\n </ul>\n </div>"
  },
  "contained" : [
    {
      "resourceType" : "ActivityDefinition",
      "id" : "1111",
      "status" : "draft",
      "productCodeableConcept" : {
        "coding" : [
          {
            "system" : "http://www.nlm.nih.gov/research/umls/rxnorm",
            "code" : "12574",
            "display" : "gemcitabine"
          }
        ],
        "text" : "gemcitabine"
      },
      "dosage" : [
        {
          "text" : "1250 mg/m² IV over 30 minutes",
          "timing" : {
            "repeat" : {
              "duration" : 30,
              "durationUnit" : "min"
            }
          },
          "route" : {
            "text" : "IV"
          },
          "doseAndRate" : [
            {
              "type" : {
                "coding" : [
                  {
                    "system" : "http://terminology.hl7.org/CodeSystem/dose-rate-type",
                    "code" : "ordered",
                    "display" : "Ordered"
                  }
                ]
              },
              "doseQuantity" : {
                "value" : 1250,
                "unit" : "mg/m²"
              }
            }
          ]
        }
      ]
    },
    {
      "resourceType" : "ActivityDefinition",
      "id" : "2222",
      "status" : "draft",
      "productCodeableConcept" : {
        "coding" : [
          {
            "system" : "http://www.nlm.nih.gov/research/umls/rxnorm",
            "code" : "40048",
            "display" : "Carboplatin"
          }
        ],
        "text" : "CARBOplatin"
      },
      "dosage" : [
        {
          "text" : "AUC 5 IV over 30 minutes",
          "timing" : {
            "repeat" : {
              "duration" : 30,
              "durationUnit" : "min"
            }
          },
          "route" : {
            "text" : "IV"
          },
          "doseAndRate" : [
            {
              "type" : {
                "coding" : [
                  {
                    "system" : "http://terminology.hl7.org/CodeSystem/dose-rate-type",
                    "code" : "ordered",
                    "display" : "Ordered"
                  }
                ]
              },
              "doseQuantity" : {
                "extension" : [
                  {
                    "url" : "http://example.org/fhir/AUC-dose",
                    "valueInteger" : 5
                  }
                ]
              }
            }
          ]
        }
      ]
    }
  ],
  "identifier" : [
    {
      "system" : "http://example.org/ordertemplates",
      "value" : "KDN5"
    }
  ],
  "version" : "1",
  "title" : "Gemcitabine/CARBOplatin",
  "type" : {
    "text" : "Chemotherapy Order Template"
  },
  "status" : "draft",
  "experimental" : true,
  "publisher" : "National Comprehensive Cancer Network, Inc.",
  "useContext" : [
    {
      "extension" : [
        {
          "url" : "http://hl7.org/fhir/StructureDefinition/usagecontext-group",
          "valueString" : "A"
        }
      ],
      "code" : {
        "system" : "http://example.org/fhir/CodeSystem/indications",
        "code" : "treamentSetting-or-diseaseStatus"
      },
      "valueCodeableConcept" : {
        "text" : "Metastatic"
      }
    },
    {
      "extension" : [
        {
          "url" : "http://hl7.org/fhir/StructureDefinition/usagecontext-group",
          "valueString" : "A"
        }
      ],
      "code" : {
        "system" : "http://example.org/fhir/CodeSystem/indications",
        "code" : "disease-or-histology"
      },
      "valueCodeableConcept" : {
        "text" : "Collecting Duct/Medullary Subtypes"
      }
    },
    {
      "extension" : [
        {
          "url" : "http://hl7.org/fhir/StructureDefinition/usagecontext-group",
          "valueString" : "A"
        }
      ],
      "code" : {
        "system" : "http://terminology.hl7.org/CodeSystem/usage-context-type",
        "code" : "focus"
      },
      "valueCodeableConcept" : {
        "text" : "Kidney Cancer"
      }
    },
    {
      "extension" : [
        {
          "url" : "http://hl7.org/fhir/StructureDefinition/usagecontext-group",
          "valueString" : "B"
        }
      ],
      "code" : {
        "system" : "http://example.org/fhir/CodeSystem/indications",
        "code" : "treatmentSetting-or-diseaseStatus"
      },
      "valueCodeableConcept" : {
        "text" : "Relapsed"
      }
    },
    {
      "extension" : [
        {
          "url" : "http://hl7.org/fhir/StructureDefinition/usagecontext-group",
          "valueString" : "B"
        }
      ],
      "code" : {
        "system" : "http://example.org/fhir/CodeSystem/indications",
        "code" : "disease-or-histology"
      },
      "valueCodeableConcept" : {
        "text" : "Collecting Duct/Medullary Subtypes"
      }
    },
    {
      "extension" : [
        {
          "url" : "http://hl7.org/fhir/StructureDefinition/usagecontext-group",
          "valueString" : "B"
        }
      ],
      "code" : {
        "system" : "http://terminology.hl7.org/CodeSystem/usage-context-type",
        "code" : "focus"
      },
      "valueCodeableConcept" : {
        "text" : "Kidney Cancer – Collecting Duct/Medullary Subtypes - Metastatic"
      }
    }
  ],
  "copyright" : "All rights reserved.",
  "approvalDate" : "2016-07-27",
  "lastReviewDate" : "2016-07-27",
  "author" : [
    {
      "name" : "Lee Surprenant"
    }
  ],
  "relatedArtifact" : [
    {
      "type" : "derived-from",
      "display" : "NCCN Guidelines for Kidney Cancer. V.2.2016",
      "url" : "http://www.example.org/professionals/physician_gls/PDF/kidney.pdf"
    },
    {
      "type" : "citation",
      "_type" : {
        "extension" : [
          {
            "url" : "http://example.org/fhir/regimenReferenceType",
            "valueCode" : "a"
          }
        ]
      },
      "citation" : "Oudard S, et al. J Urol. 2007;177(5):1698-702",
      "url" : "http://www.ncbi.nlm.nih.gov/pubmed/17437788"
    }
  ],
  "action" : [
    {
      "selectionBehavior" : "exactly-one",
      "action" : [
        {
          "selectionBehavior" : "all",
          "action" : [
            {
              "groupingBehavior" : "sentence-group",
              "selectionBehavior" : "exactly-one",
              "action" : [
                {
                  "id" : "cycle-definition-1",
                  "textEquivalent" : "21-day cycle for 6 cycles",
                  "timingTiming" : {
                    "repeat" : {
                      "count" : 6,
                      "duration" : 21,
                      "durationUnit" : "d"
                    }
                  },
                  "action" : [
                    {
                      "id" : "action-1",
                      "extension" : [
                        {
                          "extension" : [
                            {
                              "url" : "day",
                              "valueInteger" : 1
                            },
                            {
                              "url" : "day",
                              "valueInteger" : 8
                            }
                          ],
                          "url" : "http://hl7.org/fhir/StructureDefinition/timing-daysOfCycle"
                        }
                      ],
                      "textEquivalent" : "Gemcitabine 1250 mg/m² IV over 30 minutes on days 1 and 8",
                      "definitionCanonical" : "#1111"
                    },
                    {
                      "id" : "action-2",
                      "extension" : [
                        {
                          "extension" : [
                            {
                              "url" : "day",
                              "valueInteger" : 1
                            }
                          ],
                          "url" : "http://hl7.org/fhir/StructureDefinition/timing-daysOfCycle"
                        }
                      ],
                      "textEquivalent" : "CARBOplatin AUC 5 IV over 30 minutes on Day 1",
                      "relatedAction" : [
                        {
                          "actionId" : "action-1",
                          "relationship" : "concurrent-with-start"
                        }
                      ],
                      "definitionCanonical" : "#2222"
                    }
                  ]
                }
              ]
            }
          ]
        }
      ]
    }
  ]
}